The physical technique stimulates fibroblasts to produce new collagen and elastin. Then think of the fibroblasts as depleted of nutrients—hyaluronic acid, vitamin, minerals, essential amino acids, growth factors, stem cells, etc.—you can then tailor what nutrients you want to give the fibroblasts, according to a patient's needs and age.
Mesotherapy is brilliant for perpendicular lip lines, dry dehydrated lips and the barcode wrinkles patients get adjacent to the mouth and under the cheekbones.